Negative results on groundbreaking experiments are helping scientists figure out how to beat the disease. The Expedition 3 results, which showed some efficacy but not enough, being ruled a negative by the studys authors were devastating, Sperling told The Daily Beast.It was a near miss because every single cognitive measure and clinical measure showed a small benefit but not enough, Sperling said. I was so sad for the patients and very worried about A4.It can seem disheartening when the words negative appear on trial results, especially in the Alzheimers field, which has been plagued with very little movement on the clinical end of treatment for years. The disease was first discovered in 1906 by Alois Alzheimer and since then, has been difficult to treat.

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