Growing instances of bone defects among individuals has fuelled demand for the bone grafting techniques in the healthcare industry. As the need to conduct trauma and orthopedic surgeries persist, manufacturers are developing a range of bone grafts or bone graft substitutes to stimulate insufficient or impaired bone regeneration. Since each surgeon faces difficulties to select the most suitable bone graft or bone graft substitute for each trauma and orthopedic surgical procedure that requires bone grafting. Therefore, bone graft or bone graft substitute should have the properties such as the biocompatibility, osteoconductive, osteoinductive, and osteogenic properties, as well as the biomaterial should provide sufficient mechanical support to allow for an optimal biomechanical environment in which bone regeneration occur.

Since the inception of first injectable bone substitutes, there are numerous products has been introduced and commercialized for orthopedic trauma, still lack of knowledge has been observed amongst potential users about its usage and application. This unawareness denotes the sluggish growth of the injectable bone graft substitutes.

Leading manufacturers are focusing on developing a range of premixed or directly mixed products, and new compounds that contain fibers that enhances the bending and shear strength for injectable bone grafts. Furthermore, products that are based on combinations of calcium phosphate (CP) mixtures and calcium sulphate (CS) compounds are also being developed. Thus, injectable bone substitutes, particularly CS, have also been targeted as potentially good carriers for antibiotics and growth factors.

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