Researchers from UC San Diego, University of Southern California and Memorial Sloan Kettering Cancer Center in New York, have created a way to target and kill cancer cells remotely via ultrasound.The National Institutes of Health supported the project.Without being invasive, the approach makes it possible to remotely control genetic processes in live immune T cells to identify and kill cancer cells. Researchers used ultrasound to mechanically disturb T cells, and then converted the mechanical signals into genetic control of cells. In a study, they show how their remote-controlled mechanogenetics system can engineer chimeric antigen receptor (CAR)-expressing T cells that can target and kill cancer cells. The engineered CAR-T cells have mechano-sensors and genetic transducing modules that can be remotely activated by ultrasound.

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